His team gave 16 infants and children with acute lymphoblastic leukemia a folic acid inhibitor, aminopterin-10 showed improvement by clinical and hematologic parameters after three months. Based on anecdotal evidence that children with acute leukemia worsened if they were given folic acid, he worked on blocking folic acid metabolism. In June 1948, Sidney Farber reported promising results in treatment of early childhood leukemia.The neurologist would go on to describe what is now known as the Brown-Séquard syndrome. In October 1872, a lecture by Charles-Édouard Brown-Séquard was published that proposed the then-revolutionary idea that one cerebral hemisphere can influence both sides of the body.In June 1906, James Homer Wright published an article that described how he stained and studied bone marrow with descriptions of what are now known as megakaryocytes and platelets."Other severe operations have been performed without the knowledge of the patients." "A patient has been rendered completely insensible during an amputation of the thigh, regain consciousness after a short interval," Bigelow wrote. This allowed patients to remain sedated during operations ranging from dental extraction to amputation. In November 1846, Henry Jacob Bigelow, a Boston surgeon, reported a breakthrough in the search for surgical anesthetics with the first uses of inhaled ether in 1846.( August 2022) ( Learn how and when to remove this template message) Statements consisting only of original research should be removed. Please improve it by verifying the claims made and adding inline citations. This article possibly contains original research. In 1921, the Massachusetts Medical Society purchased the Journal for US$1 (equivalent to $16 in 2022) and, in 1928, renamed it to The New England Journal of Medicine. The editors of the New England Journal of Medicine and Surgery and the Collateral Branches of Medical Science purchased the weekly Intelligencer for $600 in 1828, merging the two publications to form the Boston Medical and Surgical Journal, and shifting from quarterly to weekly publication. In 1823, another publication, the Boston Medical Intelligencer, appeared under the editorship of Jerome V. Subsequently, the first issue of the New England Journal of Medicine and Surgery and the Collateral Branches of Medical Science was published in January 1812. In September 1811, John Collins Warren, a Boston physician, along with James Jackson, submitted a formal prospectus to establish the New England Journal of Medicine and Surgery and Collateral Branches of Science as a medical and philosophical journal. It is among the most prestigious peer-reviewed medical journals as well as the oldest continuously published one. The New England Journal of Medicine ( NEJM) is a weekly medical journal published by the Massachusetts Medical Society.
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